医学部 医学科 薬理学講座
教授
オオクボ ヨウヘイ
大久保 洋平

更新日: 2026/06/13
論文
[1]. Isoflurane activates the type 1 ryanodine receptor to induce anesthesia in mice.
PLoS biology [巻]23 [号]6 [頁]e3003172 (2025年) [査読] 有 [DOI]
[2]. CHCHD2 P14L, found in amyotrophic lateral sclerosis, exhibits cytoplasmic mislocalization and alters Ca2+ homeostasis.
PNAS nexus [巻]3 [号]8 [頁]pgae319 (2024年) [査読] 有 [DOI]
[3]. Investigation of Brain Functions with Fluorescence Imaging Techniques
Juntendo Medical Journal The Jutendo Medical Journal [巻]68 [号]2 [頁]157 -162 (2022年) [査読] 有 [DOI]
[4]. Astrocytic Ca2+ signaling mediated by the endoplasmic reticulum in health and disease.
Journal of pharmacological sciences [巻]144 [号]2 [頁]83 -88 (2020年) [査読] 有 [DOI]
[5]. Rational Design of a Near-infrared Fluorescence Probe for Ca2+ Based on Phosphorus-substituted Rhodamines Utilizing Photoinduced Electron Transfer.
Chemistry, an Asian journal [巻]15 [号]4 [頁]524 -530 (2020年) [査読] 有 [DOI]
[6]. Store-operated Ca2+ entry-dependent Ca2+ refilling in the endoplasmic reticulum in astrocytes.
Biochemical and biophysical research communications [巻]522 [号]4 [頁]1003 -1008 (2019年) [査読] 有 [DOI]
[7]. Visualization of astrocytic intracellular Ca2+ mobilization.
The Journal of physiology [巻]598 [号]9 [頁]1671 -1681 (2019年) [査読] 有 [DOI]
[8]. Role of Endoplasmic Reticulum-Mediated Ca2+ Signaling in Neuronal Cell Death
Antioxidants & Redox Signaling Mary Ann Liebert Inc [巻]29 [号]12 [頁]1147 -1157 (2018年) [査読] 有 [DOI]
[9]. Inositol 1,4,5-trisphosphate receptor type 2-independent Ca2+ release from the endoplasmic reticulum in astrocytes.
Glia [巻]67 [号]1 [頁]113 -124 (2018年) [査読] 有 [DOI]
[10]. Nitric Oxide-induced Activation of the Type 1 Ryanodine Receptor Is Critical for Epileptic Seizure-induced Neuronal Cell Death
EBIOMEDICINE [巻]11 [頁]253 -261 (2016年) [査読] 有 [DOI]
[11]. Whisker experience-dependent mGluR signaling maintains synaptic strength in the mouse adolescent cortex
EUROPEAN JOURNAL OF NEUROSCIENCE [巻]44 [号]3 [頁]2004 -2014 (2016年) [査読] 有 [DOI]
[12]. Visualization of Ca2+ Filling Mechanisms upon Synaptic Inputs in the Endoplasmic Reticulum of Cerebellar Purkinje Cells
JOURNAL OF NEUROSCIENCE [巻]35 [号]48 [頁]15837 -15846 (2015年) [査読] 有 [DOI]
[13]. Neuronal Regulation of Schwann Cell Mitochondrial Ca2+ Signaling during Myelination
CELL REPORTS [巻]12 [号]12 [頁]1951 -1959 (2015年) [査読] 有 [DOI]
[14]. In Vivo Visualization of Subtle, Transient, and Local Activity of Astrocytes Using an Ultrasensitive Ca2+ Indicator
CELL REPORTS [巻]8 [号]1 [頁]311 -318 (2014年) [査読] 有 [DOI]
[15]. Imaging intraorganellar Ca2+ at subcellular resolution using CEPIA
NATURE COMMUNICATIONS [巻]5 [頁]4153 (2014年) [査読] 有 [DOI]
[16]. Calcium-dependent N-cadherin up-regulation mediates reactive astrogliosis and neuroprotection after brain injury
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA [巻]110 [号]28 [頁]11612 -11617 (2013年) [査読] 有 [DOI]
[17]. Imaging of Ca2+ and Related Signaling Molecules and Investigation of Their Functions in the Brain
ANTIOXIDANTS & REDOX SIGNALING [巻]14 [号]7 [頁]1303 -1314 (2011年) [査読] 有 [DOI]
[18]. Visualization of glutamate as a volume transmitter
JOURNAL OF PHYSIOLOGY-LONDON [巻]589 [号]3 [頁]481 -488 (2011年) [査読] 有 [DOI]
[19]. Inositol 1,4,5-trisphosphate signaling maintains the activity of glutamate uptake in Bergmann glia
EUROPEAN JOURNAL OF NEUROSCIENCE [巻]32 [号]10 [頁]1668 -1677 (2010年) [査読] 有 [DOI]
[20]. Imaging extrasynaptic glutamate dynamics in the brain
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA [巻]107 [号]14 [頁]6526 -6531 (2010年) [査読] 有 [DOI]
[21]. Temporal switching and cell-to-cell variability in Ca2+ release activity in mammalian cells
MOLECULAR SYSTEMS BIOLOGY [巻]5 [頁]247 (2009年) [査読] 有 [DOI]
[22]. Regulation of neurite growth by spontaneous Ca2+ oscillations in astrocytes
JOURNAL OF NEUROSCIENCE [巻]27 [号]33 [頁]8957 -8966 (2007年) [査読] 有 [DOI]
[23]. Postsynaptic inositol 1,4,5-trisphosphate signaling maintains presynaptic function of parallel fiber-Purkinje cell synapses via BDNF
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA [巻]103 [号]22 [頁]8528 -8533 (2006年) [査読] 有 [DOI]
[24]. Cross talk between metabotropic and ionotropic glutamate receptor-mediated signaling in parallel fiber-induced inositol 1,4,5-trisphosphate production in cerebellar Purkinje cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience [巻]24 [号]43 [頁]9513 -20 (2004年) [査読] 有 [DOI]
[25]. Visualization of IP3 dynamics reveals a novel AMPA receptor-triggered IP3 production pathway mediated by voltage-dependent Ca2+ influx in Purkinje cells
NEURON [巻]32 [号]1 [頁]113 -122 (2001年) [査読] 有 [DOI]