医学部 医学科 再生医療学講座
教授
サハラ マコト
佐原 真
更新日: 2026/07/02
論文
[1]. Single-cell omics uncovers novel pathological mechanisms and therapeutic targets for congenital heart diseases: insights from integrated intercellular communication analysis.
Stem cell research & therapy (2026年) [査読] 有 [DOI]
[2]. 循環器学における臨床と基礎研究の融合 心臓再生医療の最前線
心臓 [巻]58 [頁]81 -92 (2026年) [査読] 無
[3]. Author Correction: Placental growth factor exerts a dual function for cardiomyogenesis and vasculogenesis during heart development.
Nature communications [巻]15 [号]1 [頁]283 -283 (2024年) [査読] 有 [DOI]
[4]. Epicardioid single-cell genomics uncovers principles of human epicardium biology in heart development and disease.
Nature biotechnology [巻]41 [号]12 [頁]1787 -1800 (2023年) [査読] 有 [DOI]
[5]. Placental growth factor exerts a dual function for cardiomyogenesis and vasculogenesis during heart development.
Nature communications [巻]14 [号]1 [頁]5435 -5435 (2023年) [査読] 有 [DOI]
[6]. STRA6 is essential for induction of vascular smooth muscle lineages in human embryonic cardiac outflow tract development.
Cardiovascular research [巻]119 [号]5 [頁]1202 -1217 (2023年) [査読] 有 [DOI]
[7]. Recent Advances in Generation of In Vitro Cardiac Organoids.
International journal of molecular sciences [巻]24 [号]7 (2023年) [査読] 有 [DOI]
[8]. Progress in Bioengineering Strategies for Heart Regenerative Medicine.
International journal of molecular sciences [巻]23 [号]7 (2022年) [査読] 有 [DOI]
[9]. Uncovering the molecular identity of cardiosphere-derived cells (CDCs) by single-cell RNA sequencing.
Basic research in cardiology [巻]117 [号]1 [頁]11 -11 (2022年) [査読] 有 [DOI]
[10]. Sequencing of a Chinese tetralogy of Fallot cohort reveals clustering mutations in myogenic heart progenitors.
JCI insight [巻]7 [号]2 (2022年) [査読] 有 [DOI]
[11]. Sequential Defects in Cardiac Lineage Commitment and Maturation Cause Hypoplastic Left Heart Syndrome.
Circulation [巻]144 [号]17 [頁]1409 -1428 (2021年) [査読] 有 [DOI]
[12]. An mRNA assay system demonstrates proteasomal-specific degradation contributes to cardiomyopathic phospholamban null mutation.
Molecular medicine (Cambridge, Mass.) [巻]27 [号]1 [頁]102 -102 (2021年) [査読] 有 [DOI]
[13]. Isolation of human ESC-derived cardiac derivatives and embryonic heart cells for population and single-cell RNA-seq analysis.
STAR protocols [巻]2 [号]1 [頁]100339 -100339 (2021年) [査読] 有 [DOI]
[14]. Corrigendum to "Cardiac progenitors and paracrine mediators in cardiogenesis and heart regeneration" [Semin. Cell Dev. Biol. Vol.100 (2020) 29-51].
Seminars in cell & developmental biology [巻]109 [頁]151 -151 (2021年) [査読] 有 [DOI]
[15]. Genome-wide CRISPR screen identifies ZIC2 as an essential gene that controls the cell fate of early mesodermal precursors to human heart progenitors.
Stem cells (Dayton, Ohio) [巻]38 [号]6 [頁]741 -755 (2020年) [査読] 有 [DOI]
[16]. Cardiac progenitors and paracrine mediators in cardiogenesis and heart regeneration.
Seminars in cell & developmental biology [巻]100 [頁]29 -51 (2020年) [査読] 有 [DOI]
[17]. In search of the next super models.
EMBO Molecular Medicine (2019年) [査読] 有
[18]. Cell-mediated delivery of VEGF modified mRNA enhances blood vessel regeneration and ameliorates murine critical limb ischemia.
Journal of controlled release : official journal of the Controlled Release Society [巻]310 [頁]103 -114 (2019年) [査読] 有 [DOI]
[19]. Population and Single-Cell Analysis of Human Cardiogenesis Reveals Unique LGR5 Ventricular Progenitors in Embryonic Outflow Tract.
Developmental cell [巻]48 [号]4 [頁]475 -490 (2019年) [査読] 有 [DOI]
[20]. Lnc'ed in to Cardiogenesis.
Cell stem cell [巻]22 [号]6 [頁]787 -789 (2018年) [査読] 有 [DOI]
[21]. Cardiac Progenitor Cells in Basic Biology and Regenerative Medicine.
Stem cells international [巻]2018 [頁]8283648 -8283648 (2018年) [査読] 有 [DOI]
[22]. Response to "Comment to the article 'Diverse contribution of bone marrow-derived late-outgrowth endothelial progenitor cells to vascular repair under pulmonary arterial hypertension and arterial neointimal formation'".
Journal of molecular and cellular cardiology [巻]103 [頁]137 -138 (2017年) [査読] 有 [DOI]
[23]. Expansion of cardiac progenitors from reprogrammed fibroblasts as potential novel cardiovascular therapy.
Stem cell investigation [巻]3 [頁]34 -34 (2016年) [査読] 有 [DOI]
[24]. Response to the letter by Guo et al., "Endothelial progenitor cells therapy: From bench to bedside".
International journal of cardiology [巻]205 [頁]97 -98 (2016年) [査読] 有 [DOI]
[25]. A specified therapeutic window for neuregulin-1 to regenerate neonatal heart muscle.
Annals of translational medicine [巻]3 [号]17 [頁]249 -249 (2015年) [査読] 有 [DOI]
[26]. Diverse contribution of bone marrow-derived late-outgrowth endothelial progenitor cells to vascular repair under pulmonary arterial hypertension and arterial neointimal formation.
Journal of molecular and cellular cardiology [巻]86 [頁]121 -35 (2015年) [査読] 有 [DOI]
[27]. Programming and reprogramming a human heart cell.
The EMBO journal [巻]34 [号]6 [頁]710 -38 (2015年) [査読] 有 [DOI]
[28]. Angiogenic potential of early and late outgrowth endothelial progenitor cells is dependent on the time of emergence.
International journal of cardiology [巻]186 [頁]305 -14 (2015年) [査読] 有 [DOI]
[29]. Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells.
Cell research [巻]25 [号]1 [頁]148 -148 (2015年) [査読] 有 [DOI]
[30]. Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells.
Cell research [巻]24 [号]7 [頁]820 -41 (2014年) [査読] 有 [DOI]
[31]. Deletion of angiotensin-converting enzyme 2 promotes the development of atherosclerosis and arterial neointima formation.
Cardiovascular research [巻]101 [号]2 [頁]236 -46 (2014年) [査読] 有 [DOI]
[32]. Driving vascular endothelial cell fate of human multipotent Isl1+ heart progenitors with VEGF modified mRNA.
Cell research [巻]23 [号]10 [頁]1172 -86 (2013年) [査読] 有 [DOI]
[33]. A HCN4+ cardiomyogenic progenitor derived from the first heart field and human pluripotent stem cells.
Nature cell biology [巻]15 [号]9 [頁]1098 -106 (2013年) [査読] 有 [DOI]
[34]. The ATP-binding cassette transporter ABCG2 protects against pressure overload-induced cardiac hypertrophy and heart failure by promoting angiogenesis and antioxidant response.
Arteriosclerosis, thrombosis, and vascular biology [巻]32 [号]3 [頁]654 -61 (2012年) [査読] 有 [DOI]
[35]. Nicorandil attenuates monocrotaline-induced vascular endothelial damage and pulmonary arterial hypertension.
PloS one [巻]7 [号]3 [頁]e33367 (2012年) [査読] 有 [DOI]
[36]. 症候性の腎動脈狭窄症に対する血管内超音波(intravascular ultrasound)ガイド下low-profile型ステント(Palmaz-Genesis)留置術の安全性と有効性の検討
福田記念医療技術振興財団情報 [号]23 (2010年) [査読] 無
[37]. The ATP-binding cassette transporter BCRP1/ABCG2 plays a pivotal role in cardiac repair after myocardial infarction via modulation of microvascular endothelial cell survival and function.
Arteriosclerosis, thrombosis, and vascular biology [巻]30 [号]11 [頁]2128 -35 (2010年) [査読] 有 [DOI]
[38]. A phosphodiesterase-5 inhibitor vardenafil enhances angiogenesis through a protein kinase G-dependent hypoxia-inducible factor-1/vascular endothelial growth factor pathway.
Arteriosclerosis, thrombosis, and vascular biology [巻]30 [号]7 [頁]1315 -24 (2010年) [査読] 有 [DOI]
[39]. 【高血圧診療の最前線 最新の戦略と今後の動向】二次性高血圧の診断の決め手 腎血管性高血圧
内科 南江堂 [巻]105 [号]3 [頁]417 -425 (2010年) [査読] 無
[40]. 経皮的腎動脈形成術(PTRA)により腎機能と難治性高血圧の著明な改善が得られた両側腎動脈狭窄症(RAS)の2例
心臓 日本心臓財団 [巻]42 [号]1 [頁]49 -59 (2010年) [査読] 有
[41]. ANCA関連血管炎との鑑別が問題となった血液培養陰性心内膜炎の1例
内科 南江堂 [巻]105 [号]1 [頁]177 -182 (2010年) [査読] 無
[42]. 【肺高血圧症 基礎と臨床の最前線】新たな治療法の今後の展開 遺伝子治療・細胞療法
綜合臨床 永井書店 [巻]58 [号]11 [頁]2324 -2337 (2009年) [査読] 無
[43]. Infective endocarditis by Bartonella quintana masquerading as antineutrophil cytoplasmic antibody-associated small vessel vasculitis.
Cardiology [巻]114 [号]3 [頁]208 -11 (2009年) [査読] 有 [DOI]
[44]. Fibroin, a Silk-Based Biodegradable Protein, is a Promising Material to Engineer Small-Diameter Vascular Graft
CIRCULATION [巻]118 [号]18 [頁]S1053 -S1054 (2008年) [査読] 有
[45]. Diverse contribution of bone marrow-derived cells to vascular remodeling associated with pulmonary arterial hypertension and arterial neointimal formation.
Circulation [巻]115 [号]4 [頁]509 -17 (2007年) [査読] 有 [DOI]
[46]. Three-vessel coronary artery disease complicated with congestive heart failure in a highly aged patient with tetralogy of Fallot having undergone palliative surgeries.
Internal medicine (Tokyo, Japan) [巻]45 [号]20 [頁]1147 -51 (2006年) [査読] 有
[47]. Diverse contribution of bone marrow-derived cells to vascular remodeling between systemic arteries injured mechanically and pulmonary vasculature injured by monocrotaline combined with subpneumonectomy
CIRCULATION LIPPINCOTT WILLIAMS & WILKINS [巻]114 [号]18 [頁]131 -131 (2006年) [査読] 有
[48]. New insights in the treatment strategy for pulmonary arterial hypertension.
Cardiovascular drugs and therapy [巻]20 [号]5 [頁]377 -86 (2006年) [査読] 有
[49]. Bone marrow-derived cells do not contribute appreciably to the pulmonary arterial remodeling associated with monocrotaline-incluced pulmonary hypertension in rats
CIRCULATION [巻]112 [号]17 [頁]U279 -U279 (2005年) [査読] 有
[50]. Comparison of various bone marrow fractions in the ability to participate in vascular remodeling after mechanical injury.
Stem cells (Dayton, Ohio) [巻]23 [号]7 [頁]874 -8 (2005年) [査読] 有
[51]. Soft plaque detected on intravascular ultrasound is the strongest predictor of in-stent restenosis: an intravascular ultrasound study.
European heart journal [巻]25 [号]22 [頁]2026 -33 (2004年) [査読] 有
[52]. A serum amyloid A and LDL complex as a new prognostic marker in stable coronary artery disease.
Atherosclerosis [巻]174 [号]2 [頁]349 -56 (2004年) [査読] 有
[53]. [Sex differences in coronary atherosclerosis: coronary angiography and intravascular ultrasonography].
Journal of cardiology [巻]43 [号]5 [頁]215 -21 (2004年) [査読] 有
[54]. [Development of blood examination method of serum amyloid A and LDL complex, and clinical application to prediction of cardiovascular event].
Rinsho byori. The Japanese journal of clinical pathology [巻]52 [号]1 [頁]67 -74 (2004年) [査読] 無
[55]. Arterial remodeling patterns before intervention predict diffuse in-stent restenosis: an intravascular ultrasound study.
Journal of the American College of Cardiology [巻]42 [号]10 [頁]1731 -8 (2003年) [査読] 有
[56]. Nifekalant hydrochloride, a novel class III antiarrhythmic agent, suppressed postoperative recurrent ventricular tachycardia in a patient undergoing coronary artery bypass grafting and the Dor approach.
Circulation journal : official journal of the Japanese Circulation Society [巻]67 [号]8 [頁]712 -4 (2003年) [査読] 有
[57]. [Prevention and treatment of the severe complications of myocardial infarction in chronic phase].
Nihon rinsho. Japanese journal of clinical medicine [巻]61 Suppl 5 [頁]662 -74 (2003年) [査読] 無
[58]. 【内科医と虚血性心疾患】虚血性心疾患に対する治療戦略 薬物療法から血行再建術まで 虚血性心疾患に対する生活指導
Medicina 医学書院 [巻]40 [号]1 [頁]80 -84 (2003年) [査読] 無
[59]. Megakaryoblastic transformation of chronic myelomonocytic leukemia presenting with severe bone pain.
Geriatrics and Gerontology International [巻]2 [頁]105 -109 (2002年) [査読] 有 [DOI]
[60]. Mechanisms of acute gain and late lumen loss after atherectomy in different preintervention arterial remodeling patterns.
The American journal of cardiology [巻]89 [号]5 [頁]505 -10 (2002年) [査読] 有
[61]. J wave and ST segment elevation in the inferior leads: a latent type of variant Brugada syndrome?
Japanese heart journal [巻]43 [号]1 [頁]55 -60 (2002年) [査読] 有
[62]. 【心電図を読む】ST-Tとその異常 ジギタリス効果
Heart View メジカルビュー社 [巻]5 [号]12 [頁]94 -95 (2001年) [査読] 無