Faculty Information : Hamamatsu University School of Medicine

Basic information on teaching staff

Career

1991/5/- 1995/3/ Harvard Medical School Dana-Farber Cancer Institute Postdoctoral fellow
1995/4/1- 1998/3/31 Cancer Institute, Japanese Foundation for Cancer Research Departments of Viral Oncology Research fellow
1998/4/- 2007/3/ The University of Tokyo Institute of Molecular and Cellular Biosciences Associate professor
2007/4/- 2018/3/ The University of Tokyo Institute of Molecular and Cellular Biosciences Associate professor
2018/4/- 2018/5/ The University of Tokyo Institute for Quantitative Biosciences Associate professor
2018/5/- Hamamatsu University School of Medicine Department of Biology Professor

Academic background

1986/3/ graduated Department of Biophysics and Biochemistry, Faculty of Science, The University of Tokyo 理学部生物化学科
1991/ completed The University of Tokyo Graduate School of Science Department of Biochemistry and Biophysics

Academic degrees

Doctor of Science (Biophysics and Biochemistry) The University of Tokyo

Research Areas

Life Science - Cell biology

Life Science - Molecular biology

Life Science - Functional biochemistry

Research keywords

TOR

mTOR

rapamycin

MAP kinase pathway

stress response

protein phosphatase

Subject of research

[1]. TOR（target of rapamycin）の制御機構と生理機能

Research Projects (Competitive Research Funds)

[1]. 酵母TORC1経路における細胞内アミノ酸検知機構の解明

Research activities

Papers

[1]. The oncogene-dependent resistance to reprogramming unveils cancer therapeutic targets.
Cell reports [Volume]39 [Issue]4 [Page]110721 （2022/） [Reviewed] Yes [DOI]

[2]. Coordinated regulation of TORC2 signaling by MCC/eisosome-associated proteins, Pil1 and tetraspan membrane proteins during the stress response.
Molecular microbiology [Volume]117 [Issue]5 [Page]1227 -1244 （2022/） [Reviewed] Yes [DOI]

[3]. Regulation of sphingolipid biosynthesis in the endoplasmic reticulum via signals from the plasma membrane in budding yeast.
The FEBS journal （2021/） [Reviewed] Yes [DOI]

[4]. A glutamine sensor that directly activates TORC1.
Communications Biology （2021/） [Reviewed] Yes

[5]. New Insight into HPts as Hubs in Poplar Cytokinin and Osmosensing Multistep Phosphorelays: Cytokinin Pathway Uses Specific HPts.
Plants (Basel, Switzerland) [Volume]8 [Issue]12 （2019/） [Reviewed] Yes [DOI]

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Research presentations

[1]. 2024/9/11 液胞TORC1とは独立したTORC1プールがミトコンドリアに存在するのか？酵母遺伝学フォーラム第57回研究報告会

[2]. 2024/9/9 スフィンゴ脂質量に依存した転写因子Com2の分解制御機構の解析酵母遺伝学フォーラム第57回研究報告会

[3]. 2024/3/25 シロイヌナズナFYVE1/FREE1はグルタミンに応答したTORC1活性化に関与する日本農芸化学会 2024年度大会

[4]. 2023/11/29 FYVE1 is involved in glutamine-responsive TORC1 activation in Arabidopsis thaliana. 第46回日本分子生物学会年会

[5]. 2023/8/30 細胞内スフィンゴ脂質量に依存した転写因子Com2の発現制御機構の解析酵母遺伝学フォーラム第56回研究報告会

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Memberships of academic societies

[1]. 2019/1/- 2019/1/ 日本生化学会

[2]. 日本プロテインホスファターゼ研究会

[3]. 酵母細胞研究会

[4]. 酵母遺伝学フォーラム

[5]. JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY

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Committee Career

[1]. 2020/4/- 酵母細胞研究会監事

[2]. 2017/- 2020/ 酵母遺伝学フォーラム運営委員

[3]. 2015/- 2019/ 酵母細胞研究会理事長

[4]. 2005/- 日本プロテインホスファターゼ研究会世話人

Educational activities

Allotted class

[1]. 細胞内シグナル伝達学

[2]. 生物学実験

[3]. 人間科学ゼミナールⅡ

[4]. 人間科学ゼミナールⅠ

[5]. 生命科学

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Social activities

Social Contribution

[1]. 2017/- 2022/ さきがけアドバイザー