Faculty Information : Hamamatsu University School of Medicine

School of Medicine Faculty of Medicine Internal Medicine 2(Divisions of Endocrinology & Metabolism Respiratory Medicine &Hepatology)

Assistant Professor

穗積　宏尚

HOZUMI Hironao

Last updated： 2025/05/19

Basic information on teaching staff

Career

2002/5/- Hamamatsu University School of Medicine Department of Internal Medicine Resident
2004/6/- Fujieda Municipal General Hospital Respiratory Medicine
2005/11/- SHIZUOKA CITY SHIMIZU HOSPITAL Respiratory Medicine
2006/4/- Shizuoka General Hospital
2008/4/- Hamamatsu University School of Medicine Second Division, Department of Internal Medicine
2013/8/- 2018/3/ Hamamatsu University School of Medicine Department of Emergency and Disaster Medicine Assistant professor
2018/4/- Hamamatsu University School of Medicine Second Division, Department of Internal Medicine Assistant professor
2023/11/- Hamamatsu University School of Medicine Second Division, Department of Internal Medicine Assistant professor

Academic background

2002/3/ graduated Hamamatsu University School of Medicine Faculty of Medicine School of Medicine
2013/3/ graduated Hamamatsu University School of Medicine Medical Sciences Graduate School

Academic degrees

Doctor of Philosophy (Medical Science) Hamamatsu University School of Medicine

Research Areas

Life Science - Respiratory medicine

Research keywords

Interstitial lung disease

Idiopathic interstitial pneumonia

Connective tissue disease-associated/Autoimmune interstitial lung disease

Biomarker

Idiopathic pulmonary fibrosis

Subject of research

[1]. 間質性肺炎の画像解析、膠原病肺、結核免疫、急性呼吸不全、プロテオミクス、肺線維症の病態解析と治療標的の探索・開発

Research Projects (Competitive Research Funds)

[1]. Elucidation of the Pathogenesis of Acute Exacerbation of Pulmonary Fibrosis Focusing on CIRBP and Its Therapeutic Application
[2]. Elucidation of the Pathogenesis of Pulmonary Fibrosis and Development of Novel Therapies Targeting NAMPT
[3]. Elucidation of pathogenesis and development of novel therapy for pulmonary fibrosis based on cold-inducible RNA-binding protein　
[4]. Elucidation of molecular expression and its clinical application in idiopathic interstitial pneumonia using multidisciplinary proteome analysis.
[5]. Myositis-specific antibodies and biomarkers in polymyositis/dermatomyositis-associated　interstitial lung disease
[6]. Elucidation of Intracellular Invasion Mechanism of Non-Capsular Haemophilus Influenzae and Development of Novel Therapeutic Strategy - Comprehensive Proteome Analysis Using Shotgun Method -.
[7]. 低温誘導性RNA 結合タンパクを標的とした肺線維症治療の開発

Research activities

Papers

[1]. Marked, Lasting Disease Regression and Concomitantly Induced Autoimmune Hemolytic Anemia and Hemophagocytic Lymphohistiocytosis in a Patient With Lung Adenocarcinoma and Autoantibodies Receiving Atezolizumab Plus Chemotherapy: A Case Report.
JTO clinical and research reports [Volume]3 [Issue]1 [Page]100263 -100263 （2022/） [Reviewed] Yes [DOI]

[2]. EGFR-Mutated Lung Adenocarcinoma Successfully Treated With Osimertinib After Spontaneous Transformation to SCLC and Adenocarcinoma With Neuroendocrine Differentiation: Case Report
JTO clinical and research reports [Volume]3 [Issue]1 [Page]100264 （2022/） [Reviewed] Yes [DOI]

[3]. Involvement of autophagy in exacerbation of eosinophilic airway inflammation in a murine model of obese asthma.
Autophagy [Volume]18 [Issue]9 [Page]1 -13 （2022/） [Reviewed] Yes [DOI]

[4]. Multiple organ infarction caused by aortic thrombus in a lung cancer patient with the mutation.
Respiratory medicine case reports [Volume]36 [Page]101608 （2022/） [Reviewed] Yes [DOI]

[5]. Acute exacerbation of rheumatoid arthritis-associated interstitial lung disease: mortality and its prediction model.
Respiratory research [Volume]23 [Issue]1 [Page]57 -57 （2022/） [Reviewed] Yes [DOI]

5/163 View details...

Bibliography

[1]. 2025/4/ 非結核性抗酸菌症診療 Up to Date 南江堂

[2]. 2020/6/ 間質性肺疾患診療マニュアル改訂第3版南江堂

[3]. 2014/5/1 間質性肺疾患診療マニュアル改訂第2版南江堂

Research presentations

[1]. 2022/2/ 本邦のナショナルデータベースを用いたCOVID-19の大規模疫学調査日本内科学会雑誌

[2]. 2021/12/ Atezolizumab投与後に血球貪食症候群と自己免疫性溶血性貧血を発症した進行肺腺癌の1例肺癌

[3]. 2021/12/ 神経内分泌分化を伴う術後再発に対してオシメルチニブが有効であったEGFR遺伝子変異陽性肺腺癌の1例肺癌

[4]. 2021/12/ ALK融合遺伝子陽性の進行性大細胞肺癌の1例肺癌

[5]. 2021/10/ 血中コレステロールおよび長鎖脂肪酸値は非小細胞肺がんにおけるニボルマブの有効性と関連する肺癌

5/203 View details...

Memberships of academic societies

[1]. 日本内科学会

[2]. 日本呼吸器学会

[3]. 日本呼吸器内視鏡学会

[4]. 日本アレルギー学会

[5]. 日本サルコイドーシス／肉芽腫性疾患学会

5/6 View details...

Committee Career

[1]. 2024/7/- 日本呼吸器学会非腫瘍性疾患CT用語集（英文）作成委員会

Educational activities

Allotted class

[1]. 呼吸器内科学

Social activities

Social Contribution

[1]. 2024/11/- 2025/3/ 令和７年度科学研究費助成事業（若手研究）の審査委員