School of Medicine Faculty of Medicine Molecular Biology
Assistant Professor
大畑 樹也
OHATA Tatsuya

Last updated: 2026/05/13
Basic information on teaching staff
Career
2003/4/- 国立遺伝学研究所  
2006/8/- オーストリア分子病理研究所(IMP) 
2009/10/- ケンブリッジ大学幹細胞研究センター(CSCR)
2012/9/- 現職
Research Areas
Life Science - Molecular biology
Research keywords
antisense RNA
X chromosome inactivation
long non-coding RNA
Epigenetics
EMT
cisNATs
Subject of research
[1]. 細胞の運命を左右する機能的非コードRNAの制御機構の解明
Research activities
Papers
[1]. Expression of Tumor Suppressor FHIT Is Regulated by the LINC00173-SNAIL Axis in Human Lung Adenocarcinoma.
International journal of molecular sciences [Volume]24 [Issue]23 (2023/) [Reviewed] Yes [DOI]
[2]. CCIVR2 facilitates comprehensive identification of both overlapping and non-overlapping antisense transcripts within specified regions.
Scientific reports [Volume]13 [Issue]1 [Page]14807 -14807 (2023/) [Reviewed] Yes [DOI]
[3]. p130RB2 positively contributes to ATR activation in response to replication stress via the RPA32-ETAA1 axis
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Elsevier BV [Volume]1870 [Issue]6 [Page]119484 -119484 (2023/) [Reviewed] Yes [DOI]
[4]. APOBEC3B expression is promoted by lincNMR collaborating with TGF-β-Smad pathway.
Carcinogenesis (2022/) [Reviewed] Yes [DOI]
[5]. Chromatin-remodeling factor BAZ1A/ACF1 targets UV damage sites in an MLL1-dependent manner to facilitate nucleotide excision repair.
Biochimica et biophysica acta. Molecular cell research [Volume]1869 [Issue]11 [Page]119332 (2022/) [Reviewed] Yes [DOI]
Research presentations
[1]. 2025/12/5 Dynamics of transcription-coupled de novo DNA methylation 第48回日本分子生物学会年会
[2]. 2025/9/28 EFFECTS OF TWO ACTIVE X CHROMOSOMES ON GENOMIC INSTABILITY Fusion conferences Stem Cells and Cancer Conference
[3]. 2025/9/27 Effects of two active X chromosomes on homologous recombination activities 第84回 日本癌学会学術総会
[4]. 2025/9/25 Reduced Homologous Recombination Activities in Cells with Two Active X Chromosomes Kyumpook-Hamamatsu International Symposium
[5]. 2025/9/12 Antisense regulation of the Xist gene locus responsible for X-chromosome inactivation 日本遺伝学会 奨励賞受賞講演
Prizes
[1]. 2025/9/ 日本遺伝学会 奨励賞
[2]. 2009/8/ Gordon Research Conference (GRC) Epigenetics Best poster awards
[3]. 2005/9/ 日本遺伝学会 ベストペーパー賞
Memberships of academic societies
[1]. 日本エピジェネティクス研究会
[2]. 日本分子生物学会
[3]. The Genetics Society of Japan
Educational activities
Allotted class
[1]. 分子基礎医学
[2]. Biochemistry
[3]. 蛋白質研究法
[4]. 生体構造・機能解析
[5]. 生化学実習
Social activities
Social Contribution
[1]. 2025/7/- 2025/7/ 集中講義:発生生物学(名古屋市立大学、合計7コマ)
[2]. 2025/6/24- 2024/6/24 科研費書き方セミナー(浜松医科大学研究推進委員会主催)
[3]. 2022/8/10- Academic Summer School 2022 "Extracting DNA from Broccoli"